TOPOLOGY THAT MAKES A MITOCHONDRION
THE MINIMAL FUNCTIONAL TOPOLOGY THAT MAKES A MITOCHONDRION AN OPERATING SYSTEM Part I — Reframing the Object 1. From Organelle to Operating System 1.1 Why a mitochondrion is not adequately described as a bag of biochemical reactions 1.2 Molecules, interactions, functions, and system organization as distinct layers 1.3 Execution trace versus operating architecture 1.4 Why protein-interaction networks describe activity but not system identity 1.5 Function as transformation, not attribute 1.6 Persistence as the primary systems problem 1.7 The mitochondrion as a continuously executing constrained system 1.8 The central question: what functionality cannot be removed without destroying mitochondrial identity? 2. Rashevsky → Rosen → Functional Topology 2.1 Rashevsky’s shift from quantitative biophysics to relational biology 2.2 Organization before material composition 2.3 Biological topology as topology of functional relations 2.4 Rosen’s correction: interaction is insufficient without ...